Department of Biology
Biology Faculty Profile
Victor Corces
Arts & Sciences Distinguished Professor
Office Phone: 404-727-4250 | Lab Phone: 404-727-4250
Office Room: Rollins 1071B
Office Address: Emory University, Department of Biology, O. Wayne Rollins Research Center, 1510 Clifton Road NE, Atlanta , GA 30322
Lab Room: Rollins 1071B
Lab Website

Research Area:
Genetics, Cell, and Developmental Biology

Graduate Program Affiliation:
Biochemistry, Cell & Developmental Biology
Genetics and Molecular Biology


B.S., Universidad Complutense, Madrid, Spain, 1975
Ph.D., Universidad Autonoma, Madrid, Spain, 1978

The goal of our research is to understand epigenetic mechanisms controlling the expression of eukaryotic genes. We are interested in the role of the primary structure of the chromatin fiber, as determined by histone tail modification, in the regulation of transcription. In particular, we have found that phosphorylation of hitone H3 is an essential step during the promoter clearance process in the transcription of all Drosophila genes. The levels of phosphorylated histone H3 are maintained by a balance between the activities of the JIL-1 kinase and the PP2A protein phosphatase. We are currently exploring the mechanisms by which the activity of these two enzymes is regulated to control chromatin structure and transcription. A second focus of our lab is to study the organization of the chromatin fiber within the eukaryotic nucleus and the mechanisms controlling this arrangement, with the idea that nuclear organization carries epigenetic information. Sequences involved in the establishment and/or maintenance of nuclear organization are called chromatin insulators. We have identified several different proteins that form a complex with insulator DNA and we are in the process of analyzing their function. The working hypothesis we are currently testing is that insulators are responsible for controlling patterns of nuclear organization required for cell differentiation. Alterations in insulator function that disrupt this organization could lead to cancer and other diseases.

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