Some Recent Publications from the Lab

Drosophila X chromosome chromatin remodeling:

Smith, E., A. Pannuti, W. Gu, A. Steuernagel, R.G. Cook, C. D. Allis and J. C. Lucchesi.  2000.  The Drosophila MSL complex acetylates histone H4 at lysine 16, a chromatin modification linked to dosage compensation. Mol. Cell. Biol. 20: 312-318.

Gu, W., Pannuti, A. and J. C. Lucchesi  2000  Targeting the Chromatin-remodeling MSL complex of Drosophila to its sites of action on the X chromosome requires both acetyl transferase and ATPase activities. EMBO J. 19: 5202-5211.

Pannuti, A., and J. C. Lucchesi  2000  Recycle to remodel: evolution of dosage compensation complexes. Curr. Opin. Genet. Devel. 10: 644-650.

Eisen, A., Utley, R.T., Nourani, A., Allard, S., Schmidt, P., Lane, W.S., Lucchesi, J.C., and J. Cote  2001  The yeast NuA4 and Drosophila MSL complexes contain homologous subunits important for transcriptional regulation. J Biol. Chem. 276: 3484-3491.

Vogt, S., G. Schneider, A. Steuernagel, J. Lucchesi, E. Schultze, R. Rudolph, and G. Schmahl  2001  X-ray microscopic studies of the Drosophila dosage compensation complex. J. Struct. Biol. 132 : 123-132.

Smith, E.R., Allis, C.D., and J. C. Lucchesi  2001 Linking global histone acetylation to the transcription enhancement of X-chromosomal genes in Drosophila males. J Biol Chem,  276: 31483-31486.

Sass, G.L., Pannuti, A., and J.C. Lucchesi  2003  Male-specific lethal complex of Drosophila targets activated regions of the X chromosome for chromatin remodeling. Proc. Nat. Acad. Sci. USA, 100:8287-8291.

Lucchesi, J.C.  2004.  Reproduction and Development:  Dosage Compensation.  In:  Comprehensive Molecular Insect Science, L.I. Gilbert, K. Iatrou, and S.S. Gill, editors, pp. 237-245 (Elsevier/Pergamon).

John C. Lucchesi, William G Kelly, and Barbara Panning 2005 Chromatin remodeling in dosage compensation. Ann. Rev. Genetics 39: 615-651.

Human chromatin remodeling:

Pardo, P.S., Leing, J.K., Lucchesi, J.C., and O. Pereira-Smith  2002  MRG15 a novel chromodomain protein is present in two distinct multiprotein complexes involved in transcription activation. J. Biol. Chem., 277:50860-6.

Gupta, A., G.G. Sharma, C.S.H. Young, M. Agarwal, E. R. Smith, J.C. Lucchesi, K.K. Khanna, T. Ludwig, and T.K. Pandita.  2005.  Involvement of human MOF in ATM function. Molec. Cell. Biol., 25:5292-305.

Smith E.R., Cayrou, C., Huang, R., Lane, W.S., Côté, J., and J. C. Lucchesi 2005  A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16. Mol. Cell Biol., 25:9175-9188.