B. S. (Biology), University of Houston, TX B.S. 1978.
Ph. D. (Mol. Biology), Washington University, St. Louis, MO, 1985.
Graduate, Molecular Biology and Cellular Program:
1979-1985, with Dr. Meng-Chao Yao, Washington University, Biology Department.
Determination of the role of C4A2 repeats and adjacent sequences in genome rearrangement in macronuclear development in the ciliate, Tetrahymena.Post-doctoral:
1985-1987, with Dr. Shozo Yokoyama, Washington University, Department of Psychiatry.
Characterization and analyses of human alcohol dehydrogenase genes to evaluate the relationship between alcohol dehydrogenase genes and alcohol sensitivity.Post-doctoral:
1987-1991, with Dr. Shozo Yokoyama, University of Illinois at Urbana-Champaign, Ecology, Ethology & Evolution Department;
1991-1993 at Syracuse University, Biology Department.
Functional differentiation of red and green color vision; determination of mutation accumulation of the blind cave fish opsin genes compared to its eyed counterpart, Astyanax fasciatus.Research assistant professor:
1993-1996 at Syracuse University, Biology Department.
Continuation of opsin studies; site-directed mutagenesis and cell culture tissue expression of fish opsin; molecular characterization of rod- and cone-specific transducins.Research Scientist:
1996-2000, with Dr. Mary Pierce, SUNY Upstate Medical University, Department of Neuroscience & Physiology.
Functional promoter analyses of quail and chicken red visual pigment genes and gene expression studies of various genes to determine the molecular bases of circadian rhythm.Research Assistant Professor:
2000-2002, with Dr. Michael W. Miller, SUNY Upstate Medical University, Department of Neuroscience & Physiology.
Effect of alcohol on brain development.Research Scientist:
2002-2003, with Dr. David R. Mitchell, SUNY Upstate Medical University, Department of Cell & Developmental Biology.
Cloning and characterization of genes involved in the regulation and/or transport of dynein motor assembly in Chlamydomonas.
1979-1984, National Institution of Health Predoctoral Fellow, Washington University.
1987-1989, National Institute on Alcohol Abuse and Alcoholism Postdoctoral Fellow, University of Illinois at Urbana-Champaign.
Yokoyama, S., J. P. Rice & Yokoyama, R. W. (1980).
The effect of social selection due to familial mental retardation on the marriage frequency of normal individuals. Soc. Biol. 27:194-198.Yokoyama, R. W. & M.-C. Yao (1984).
Elimination of DNA sequences during macronuclear differentiation in Tetrahymena thermophila as detected by in situ hybridization. Chromosoma 85:11-22.Yokoyama, R. W. & M.-C. Yao (1984).
Internal micronuclear DNA regions which include sequences homologous to macronuclear telomeres are deleted during development in Tetrahymena. Nucl. Acids Res. 12:6103-6116.Yokoyama, R. & M.-C. Yao (1986).
Sequence characterization of Tetrahymena macronuclear DNA ends. Nucl. Acids Res. 14:2109-2122.Yokoyama, S. & Yokoyama, R. (1987).
Molecular evolution of mammalian class I alcohol dehydrogenase. Mol. Biol. Evol. 4:504-513.Yokoyama, S., Yokoyama, R. & P. Rotwein (1987).
Molecular characterization of cDNA clones encoding the human alcohol dehydrogenase b1 and the evolutionary relationship to the other class I subunits a and g. Jpn. J. Genet. 62:241-256.Yokoyama, S. & Yokoyama, R. (1989).
Molecular evolution of human visual pigment genes. Mol. Biol. Evol. 6:186-197.Matsuo, Y., Yokoyama, R. & Yokoyama, S. (1989).
Human alcohol dehydrogenases b1 and b2 are specified by a single nucleotide difference. Eur. J. Biochem. 183:317-320.Yokoyama, R. & Yokoyama, S. (1990).
Isolation, DNA sequence and evolution of a color visual pigment gene of the blind cave fish Astyanax fasciatus. Vision Res. 30:807-816.Yokoyama, R. & Yokoyama, S. (1990).
Convergent evolution of the red- and green-like visual pigment genes in fish, Astyanax fasciatus, and human. Proc. Natl. Acad. Sci. USA 87:9315-9318.Yokoyama, S., Yokoyama, R., Kinlaw, C. S. & Harry, D. E. (1990).
Molecular evolution of the zinc-containing long-chain alcohol dehydrogenase genes. Mol. Biol. Evol. 7:143-154.Yokoyama, S. & Yokoyama, R. (1990).
Molecular evolution of visual pigment genes and other G-protein coupled receptor genes. In: Population Biology of Genes and Molecules, N. Takahata & J. F. Crow (eds.), pp. 307-322, Baifukan, Tokyo.Yokoyama, S., Matsuo, Y., Rajasekharan, S. & Yokoyama, R. (1992).
Molecular structure of the human alcohol dehydrogenase 3 gene. Jpn. J. Genet. 67:167-171.Yokoyama, S., Starmer, W. T. & Yokoyama, R. (1992).
Paralogous origin of the red- and green-sensitive visual pigment genes in vertebrates. Mol. Biol. Evol. 10:527-538.Yokoyama, R. & Yokoyama, S. (1993).
Molecular characterization of a blue visual pigment gene in the fish (Astyanax fasciatus). FEBS Lett. 334:27-31.Register, E. A., Yokoyama, R. & Yokoyama, S. (1994).
Multiple origins of the green-sensitive opsin genes in fish. J. Mol. Evol. 39:268-273.Yokoyama, S., Matsuo, Y., Ramsbotham, R. & Yokoyama, R. (1994).
Molecular characterization of a class IV human alcohol dehydrogenase gene (ADH7). FEBS Lett. 351:411-415.Yokoyama, R., Knox, B. E. & Yokoyama, S. (1995).
Rhodopsin from the fish, Astyanax: Role of tyrosine 261 in the red-shift. Invest. Ophthamol. Vision Sci. 36:939-945.Yokoyama, S., Meany, A., Wilkens, H. & Yokoyama, R. (1995).
Initial mutational steps towards loss of opsin gene function in cavefish. Mol. Evol. Biol. 12:527-532.Yokoyama, S. & Yokoyama, R. (1996).
Adaptive evolution of photoreceptors and visual pigments in vertebrates. In: Annu. Rev. Ecol. Syst. 27:543-567.Yokoyama, S. & Yokoyama, R. (2000).
Comparative molecular biology of visual pigments. In: Handbook of Biological Physics, Vol. 3, Molecular Mechanisms in Visual Transduction, pp. 257-296. (D.G. Stavenga, W.J. deGrip, E.N. Pugh, Jr., Eds.).Miller, M. W., Jacobs, J. S. & Yokoyama, R. (2003).
Neg, a nerve growth factor-stimulated gene expressed by fetal neocortical neurons that is downregulated by ethanol. J. Comp. Neurology 460:212-222.
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